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    首頁> 外文期刊>IEEE Transactions on Magnetics >Detection of Monosodium Urate Crystals for Gout Diagnosis Using Magnetic Fields and Near-Infrared Light
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    Detection of Monosodium Urate Crystals for Gout Diagnosis Using Magnetic Fields and Near-Infrared Light

    機譯:磁場和近紅外光檢測尿酸單鈉晶體用于痛風診斷

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    摘要

    Gouty arthritis is caused by hyperuricemia, and it can develop even when the serum urate level is controlled. Methods to recognize and identify symptoms include polarization microscopy, X-ray imaging, dual-energy computed tomography, magnetic resonance imaging, and ultra-sonography. However, each method has disadvantages, such as not meeting the need for early diagnosis. Hence, no satisfactory method has been established, and alternatives to measuring serum urate levels are desired. Because monosodium urate (MSU) crystals can be rotated by applied magnetic fields, we investigated a method to noninvasively detect the crystals in vivo using magnetic fields and near-infrared light. Because near-infrared light passes through the human body, diagnosis of gout can be performed noninvasively from outside the body. MSU crystals that are equal in size to those accumulated in the human body were prepared in calf serum. Magnetically induced changes in reflected near-infrared light intensity were measured with a spectrophotometer. Specifically, 800–850 nm reflected light intensity changed 5% at 300 mT. Therefore, it may be possible to detect the existence of MSU crystals for the diagnosis of gout by using near-infrared light and a magnetic field.
    機譯:痛風性關節炎是由高尿酸血癥引起的,即使在控制血清尿酸水平的情況下也可以發展為痛風性關節炎。識別和識別癥狀的方法包括極化顯微鏡,X射線成像,雙能計算機斷層掃描,磁共振成像和超聲檢查。但是,每種方法都有缺點,例如不能滿足早期診斷的需要。因此,尚未建立令人滿意的方法,并且需要替代方法來測量血清尿酸鹽水平。由于尿酸單鈉(MSU)晶體可以通過施加的磁場旋轉,因此我們研究了一種使用磁場和近紅外光在體內無創檢測晶體的方法。由于近紅外光穿過人體,因此可以從人體外部無創地診斷痛風。在小牛血清中制備了與人體內積累的MSU晶體大小相等的MSU晶體。用分光光度計測量磁感應的反射近紅外光強度的變化。具體來說,在300 mT處800-850 nm的反射光強度改變了5%。因此,有可能通過使用近紅外光和磁場來檢測MSU晶體的存在,以診斷痛風。

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