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    Albumin research in the 21st century

    機譯:21世紀的白蛋白研究

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    摘要

    It is important to recognize that most of our current knowledge of serum albumin stems from many centuries of research. In the days before serum albumin was recognized, scientists and physicians studied "albuminous material" in fluids of the body. For instance, Hippocrates of Cos, known as The Father of Modern Medicine, in his Aphorisms in 400 B.C. noticed that the urine foamed in patients with renal disease [1 ]. A millennium later, the Swiss physician, Paracelsus, who had a reputation for being arrogant but was a credible scientist, pioneered the use of chemicals in medicine, and reported turbidity in urine with addition of vinegar [2]. Frederick Dekkers, publishing in Leiden, The Netherlands, in 1694, compared the urine of consumptives to milk, being coagulable with heat and acetic acid [3], Nearly a century later, in 1764, Dominico Cotugno of Bari treated the severe dropsy of a soldier with potassium tartrate and provoked a massive diuresis, the urine of which upon heating became a white mass, "like egg albumin" [4].In 1839, the eminent physiologist Henry Ancell at St. Georges Hospital, London gave detailed lectures on the blood [5]. He accurately reported the content of albuminous substance or "albumen" (= total protein) in blood serum as 71 g/1. He refuted the proposal of M. Denis of Switzerland that albumen is "merely fibrine in solution".
    機譯:重要的是要認識到,我們目前對血清白蛋白的大多數知識都源于許多世紀的研究。在認識到血清白蛋白的前幾天,科學家和醫生研究了人體液體中的“白質物質”。例如,公元前400年的格言中被稱為現代醫學之父的希波克拉底·科斯(Hippocrates of Cos)。注意到腎病患者尿液起泡沫[1]。一千年后,瑞士醫生帕拉塞爾蘇斯以傲慢自大而又是一位可靠的科學家而聞名,他率先在藥物中使用化學藥品,并報道了尿液混濁加醋[2]。弗雷德里克·德克斯(Frederick Dekkers)于1694年在荷蘭的萊頓(Leiden)出版,將消費品的尿液與牛奶,熱和乙酸可凝結的牛奶進行了比較[3]。近一個世紀后的1764年,巴里的多米尼克·科圖尼奧(Dominico Cotugno)處理了一名酒石酸鉀士兵,引起大量利尿,加熱后尿液變成白色團塊,像蛋清一樣[4]。1839年,倫敦圣喬治醫院的著名生理學家亨利·安塞爾(Henry Ancell)進行了詳細的演講。血[5]。他準確地報告了血清中白蛋白或“白蛋白”(=總蛋白)的含量為71 g / 1。他駁斥了瑞士丹尼斯先生的提議,即蛋白僅是溶液中的纖維蛋白。

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